MOTRIN® Arthritis Pain Relief Diclofenac Sodium Topical Gel 1%. This topical gel with 1% diclofenac sodium, a nonsteroidal anti-inflammatory drug (NSAID), is clinically proven to relieve arthritis joint pain. This original prescription strength topical NSAID analgesic cream works to reduce inflammation in hands, wrists, elbows, feet, ankles, and knees, improves mobility and reduces joint stiffness.